Recent SARS News
Exploring the influence of enforcing infection control directives on the risk of developing healthcare associated infections in the intensive care unit: A retrospective study
Posted from MedWorm: SARS 3 days ago
SARS : News and Information
Conclusion: Our findings suggest that strict enforcement of infection control strategies may have a positive impact on the efforts to minimise the risk of HAIs. These findings carry a clinical significance that shall not be ignored with regard to our overall efforts to minimise the risk of developin... (original story)
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Tamiflu's Effectiveness Remains Uncertain - Roche Still Not Releasing Vital Trial Data
Posted from MedWorm: SARS 6 days ago
SARS : News and Information
Two years ago, pharmaceutical giant, Roche, promised the BMJ to release key Tamiflu trial data for an independent investigation. However, Roche refuses to provide full access to all its data. According to a new report by the Cochrane Collaboration, Roche's refusal to provide access leaves critical c... (original story)
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Anti-Influenza Drug Surrounded By Continuing Uncertainties
Posted from MedWorm: SARS 6 days ago
SARS : News and Information
Incomplete availability of data has hampered a thorough assessment of the evidence for using the anti-influenza drug oseltamivir, a Cochrane Review has found. However, after piecing together information from over 16,000 pages of clinical trial data and documents used in the process of licensing osel... (original story)
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Flu Pandemics And La Nina
Posted from MedWorm: SARS 6 days ago
SARS : News and Information
Worldwide pandemics of influenza caused widespread death and illness in 1918, 1957, 1968 and 2009. A new study examining weather patterns around the time of these pandemics finds that each of them was preceded by La Nina conditions in the equatorial Pacific. The study's authors - Jeffrey Shaman of C... (original story)
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'Google Flu Trends' A Powerful Early Warning System For Emergency Departments
Posted from MedWorm: SARS 13 days ago
SARS : News and Information
Monitoring Internet search traffic about influenza may prove to be a better way for hospital emergency rooms to prepare for a surge in sick patients compared to waiting for outdated government flu case reports. A report on the value of the Internet search tool for emergency departments, studied by a... (original story)
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Medicinal chemistry of indolylglyoxylamide GABA(A)/BzR high affinity ligands: identification of novel anxiolytic/non sedative agents.
Posted from MedWorm: SARS 16 days ago
SARS : News and Information
Authors: Salerno S, Da Settimo F, Taliani S, Simorini F, La Motta C, Fornaciari G, Marini AM Abstract The classical benzodiazepines (Bz) constitute a well-known class of therapeutics displaying hypnotic, anxiolytic and anticonvulsant effects acting upon a specific binding site (BzR) belongin... (original story)
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Medicinal Chemistry of Indolylglyoxylamide TSPO High Affinity Ligands with Anxiolytic-Like Effects.
Posted from MedWorm: SARS 16 days ago
SARS : News and Information
Authors: Simorini F, Marini AM, Taliani S, La Motta C, Salerno S, Pugliesi I, Da Settimo F Abstract The mitochondrial translocator protein (TSPO) mediates the synthesis of neurosteroids in the CNS, which have been demonstrated to enhance the neurotransmitter GABA response, exhibiting related... (original story)
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SARS-CoV nucleocapsid protein interacts with cellular pyruvate kinase protein and inhibits its activity
Posted from MedWorm: SARS 16 days ago
SARS : News and Information
Abstract The pathogenesis of SARS-CoV remains largely unknown. To study the function of the SARS-CoV nucleocapsid protein, we have conducted a yeast two-hybrid screening experiment to identify cellular proteins that may interact with the SARS-CoV nucleocapsid protein. Pyruvate kinase (l... (original story)
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VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA
Posted from MedWorm: SARS 16 days ago
SARS : News and Information
RNAi technology has been emerging as a potential modality to inhibit viruses during past decade. In literature a few siRNA databases have been reported that focus on targeting human and mammalian genes but experimentally validated viral siRNA databases are lacking. We have developed VIRsiRNAdb, a ma... (original story)
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Design and Synthesis of 2‐Iminothiazolidin‐4‐one Moiety‐Containing Compounds as Potent Antiproliferative Agents
Posted from MedWorm: SARS 16 days ago
SARS : News and Information
AbstractA new series of 2,5‐diaryliminothiazolidin‐4‐ones were designed and synthesized as potent antiproliferative agents. The antiproliferative activities of the 25 target compounds were evaluated against three cancer cell lines (A549, H460 and HT29) by MTT assay. Pharmacological data indica... (original story)
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